The incidence of immunodeficiency and autoimmune diseases continues to increase annually, especially in countries with an underdeveloped pharmaceutical market, making insect therapy a widely used treatment. The goal of this research is to investigate the potential of using Ulomoides dermestoides beetles as a raw material for the development of an immunomodulatory agent. A review of the available literature revealed the therapeutic potential of U. dermestoides beetles in the treatment of various health conditions. During the study, the biologically active supplement “Immutoron” was created from U. dermestoides biomass. To evaluate the effect of the beetles' diet on the final product, 3 different formulations were produced using the beetles-fed banana peel, sunflower meal, and apple pulp. The resulting supplement was administered to rats, and several indicators, including behavior, body temperature, white blood cell count, erythrocytes, hemoglobin, cholesterol, and total protein levels, were compared with those of a control group. The results showed that the high content of chitin and melanin in the beetles contributed to the antioxidant and immunomodulatory effects of the supplement, with no observed toxicity in the experimental animals.
