The Periplaneta Americana, an important household insect, plays a crucial role in transmitting various pathogens in the environment. Traditional methods of controlling this pest have often been ineffective and have led to the development of resistance. This study aimed to evaluate the lethal effects of titanium oxide nanoparticles, both by contact and ingestion, on Periplaneta Americana. Different concentrations of nanoparticles were prepared for oral and contact applications. The insects were exposed to these treatments with varying nanoparticle concentrations across three repetitions. The mean mortality rates among the groups were analyzed using a one-way analysis of variance and Duncan's test. In addition, the mortality rates observed on different days were compared using repeated measures analysis of variance. The oral application of titanium oxide nanoparticles showed higher efficacy than the contact method at concentrations of 15% and 21% across all days, while the contact method was more effective than the oral method at a 25% concentration, except on the seventh day. Overall, the oral treatment showed better efficacy than the contact treatment. As the concentration increased and over time, the mortality rate of Periplaneta Americana increased significantly with both treatment methods. These findings suggest that the use of titanium dioxide nanoparticles, in combination with existing control methods, could provide a promising approach to managing Periplaneta Americana infestations.
