Seven novel porcine parvoviruses (nPPVs), designated PPV2 through PPV8, have been identified, though their pathogenic potential and contribution to porcine reproductive failure (PRF) remain unclear. The present investigation examined the occurrence of these nPPVs in gilts from Colombia, explored their coinfections with PPV1, PCV2, PCV3, PCV4, and PRRSV, and assessed possible links between nPPV detection and reproductive performance parameters (RPPs) in sows. A total of 234 serum samples were obtained from healthy gilts across 40 herds distributed in five Colombian regions, and real-time PCR was used for viral detection. Circulation of PPV2 through PPV7 was confirmed in Colombia, with PPV3 (40%), PPV5 (20%), and PPV6 (17%) being the most common. Neither PCV4 nor PPV8 was found. Multiple concurrent infections were observed among PPV2–PPV7 and the primary PRF-associated viruses, ranging from dual to sextuple coinfections. Statistical analysis revealed significant associations: PPV6 was more frequent in PCV3-positive gilts (p < 0.01) and PPV5 in PRRSV-positive gilts (p < 0.05), whereas PPV3 was notably present in PCV2-negative (p < 0.01) and PRRSV-negative (p < 0.05) animals. Considering RPPs, only PCV3 showed a significant correlation with the farrowing rate (FR)—the likelihood of a low FR was 94% lower in herds harboring PCV3-positive gilts (OR 0.06, p = 0.0043), suggesting that detection of PCV3 by PCR correlates with improved reproductive outcomes. Furthermore, PPV4 and PPV5 showed a tendency to associate with reduced FR (p < 0.20). These findings contribute to clarifying the potential involvement of nPPVs in PRF within Colombian swine herds.
