A two-year-old ball python presenting with a submandibular swelling was examined. Fine-needle aspiration yielded purulent debris containing bacterial organisms. Radiographs revealed multiple radiopaque regions within the mass, suggestive of mineralization, but no mandibular or pulmonary involvement. Grossly, the excised lesion was multi-nodular, well-defined, and contained purulent material. Postoperative recovery was smooth. Histopathology followed by immunohistochemical testing confirmed the lesion as a leiomyosarcoma because neoplasms containing pus-like material can mimic abscesses; therefore, comprehensive diagnostic evaluation using multiple modalities is advised.
