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International Journal of Veterinary Research and Allied Sciences

2022 Volume 2 Issue 1
Creative Commons License

Innovative Biotechnological Variants of Nutritional Supplements Targeting Gut Dysbiosis and Their Clinical Evaluation


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  1. Department of Technological Entrepreneurship, Kuzbass State Agricultural Academy, Kemerovo, Russia.
  2. Scientific and Educational Center for Applied Biotechnology and Nutrition, Kemerovo State Medical University, Kemerovo, Russia.
  3. Department of Management, Entrepreneurship, and Engineering, Ural State University of Economics, Ekaterinburg, Russia.
Abstract

This study focuses on novel biotechnological formulations of nutritional supplements designed to support individuals dealing with gut dysbiosis. Four distinct supplements have been formulated to help prevent and manage gastrointestinal disorders, each with specific properties. The first supplement incorporates modified sorbents to neutralize bacterial endotoxins. The second supplement consists of microencapsulated live strains of Bifidobacterium and Lactobacillus to support immune function. The third supplement contains bacterial metabiotics that facilitate endotoxin absorption and promote a balanced intestinal microbiota. The fourth supplement is derived from plant-based components that encourage the growth of beneficial microbiota by suppressing the proliferation of yeasts and pathogenic bacteria, while also having protective and anti-inflammatory properties. A clinical trial was conducted with 10 volunteers aged 33-72 years, who consumed these four supplements orally. The dosage regimen and duration of treatment were systematically tested, evaluated, and validated. Various health parameters, including biochemical, hematological, and immunological blood profiles, along with fecal sugar levels, occult blood in feces, and coprogram results, were assessed before and after supplementation. The findings confirmed the effectiveness of these nutritional supplements in alleviating gut dysbiosis.


How to cite this article
Vancouver
Vekovtsev AA, Zakharenko MA, Gorbushina IS, Pliska OV, Poznyakovsky VM, Tokhiriyon B, et al. Innovative Biotechnological Variants of Nutritional Supplements Targeting Gut Dysbiosis and Their Clinical Evaluation. Int J Vet Res Allied Sci. 2022;2(1):31-6. https://doi.org/10.51847/qerJQpA1uI
APA
Vekovtsev, A. A., Zakharenko, M. A., Gorbushina, I. S., Pliska, O. V., Poznyakovsky, V. M., Tokhiriyon, B., & Chelnakova, N. G. (2022). Innovative Biotechnological Variants of Nutritional Supplements Targeting Gut Dysbiosis and Their Clinical Evaluation. International Journal of Veterinary Research and Allied Sciences, 2(1), 31-36. https://doi.org/10.51847/qerJQpA1uI

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