This study focuses on novel biotechnological formulations of nutritional supplements designed to support individuals dealing with gut dysbiosis. Four distinct supplements have been formulated to help prevent and manage gastrointestinal disorders, each with specific properties. The first supplement incorporates modified sorbents to neutralize bacterial endotoxins. The second supplement consists of microencapsulated live strains of Bifidobacterium and Lactobacillus to support immune function. The third supplement contains bacterial metabiotics that facilitate endotoxin absorption and promote a balanced intestinal microbiota. The fourth supplement is derived from plant-based components that encourage the growth of beneficial microbiota by suppressing the proliferation of yeasts and pathogenic bacteria, while also having protective and anti-inflammatory properties. A clinical trial was conducted with 10 volunteers aged 33-72 years, who consumed these four supplements orally. The dosage regimen and duration of treatment were systematically tested, evaluated, and validated. Various health parameters, including biochemical, hematological, and immunological blood profiles, along with fecal sugar levels, occult blood in feces, and coprogram results, were assessed before and after supplementation. The findings confirmed the effectiveness of these nutritional supplements in alleviating gut dysbiosis.
