TY  - JOUR
T1  - Proteostasis, Membrane Stability, Metabolic Regulation, and Repair Together Define the Molecular Logic of Insect Thermal Tolerance
A1  - Maria Silva
A1  - Joao Pereira
A1  - Bruno Costa
A1  - Ricardo Alves
JF  - Entomological Research Letters
JO  - Entomol Res Lett
SN  - 3108-639X
Y1  - 2024
VL  - 4
IS  - 2
DO  - 10.51847/8Dm1G0q7Y3
SP  - 52
EP  - 62
N2  - Insect thermal tolerance is commonly interpreted through individual responses such as heat-shock proteins, antioxidant enzymes, lipid remodeling, or metabolic adjustment. These processes, however, operate at different biological levels and need not vary together across taxa, life stages, or exposure regimes. This article develops a proposed molecular-physiological model in which thermal tolerance depends on coordinated preservation of proteome integrity, membrane and lipid state, energetic supply, and damage control and repair. Cellular stress signaling is treated as context-sensitive regulation rather than a universal master switch. The synthesis separates functional evidence from association, molecular response from organismal performance, and acute protection from longer-duration maintenance. Evidence across Diptera, Lepidoptera, Hemiptera, Hymenoptera, and Coleoptera indicates that component importance and direction can vary with species, developmental stage, oxygen and resource state, and exposure duration. The contribution is therefore not a conserved pathway but an evidence-bounded coordination logic that generates testable predictions about when canonical stress responses should remain compensatory or become insufficient.
UR  - https://esvpub.com/article/proteostasis-membrane-stability-metabolic-regulation-and-repair-together-define-the-molecular-log-cy0hkz5rw7pljhi
ER  -