TY  - JOUR
T1  - Chronic Domestic Cat Hepadnavirus Infection in a Feline Patient with Liver Disease: Integrated Serological, Molecular, and Genomic Diagnosis
A1  - Fu Yang
A1  - Kang Wen
A1  - Shao Peng
A1  - Jian Hua
JF  - International Journal of Veterinary Research and Allied Sciences
JO  - Int J Vet Res Allied Sci
SN  - 3062-357X
Y1  - 2023
VL  - 3
IS  - 1
DO  - 10.51847/411utjnvek
SP  - 96
EP  - 102
N2  - A stray female domestic shorthair cat, approximately three years of age, presenting with biochemical and clinical evidence of liver dysfunction, was confirmed to be infected with domestic cat hepadnavirus (DCH). Integration of molecular testing and antibody profiling suggested a chronic infection phase, as IgM anti-core antibodies—commonly linked to acute Hepatitis B Virus (HBV) cases—were undetectable. In contrast, IgG anti-core antibodies were identified, consistent with chronic HBV infections in humans. The absence of anti-DCH surface antibodies indicated no seroconversion or long-term immune protection. Genomic analysis demonstrated 98.3% sequence similarity to Italian DCH isolates.
UR  - https://esvpub.com/article/chronic-domestic-cat-hepadnavirus-infection-in-a-feline-patient-with-liver-disease-integrated-serol-swkjr9tfphgptfy
ER  -